HTC still tripping Samsung up in Windows Phone race






It is not clear that Samsung (005930) even cares — but HTC (2498) continues outmaneuvering its far bigger rival when it comes to Windows Phones. The budget HTC Windows Phone 8S is no available from UK operator Three starting at the notably low £17 per month contract price. This is about half of what the monthly contract price of Samsung’s ATIV S Windows Phone model is expected to cost in the UK. Once it finally arrives. Possibly during the last week of the year. There is no firm word on when ATIV S might arrive on AT&T (T) and Verizon (VZ) at this point.


So not only did Samsung miss the U.S. and European Christmas sales seasons completely with its first Windows Phone 8 device, HTC actually managed to get both the high-end Windows Phone 8X and the budget 8S out before Christmas in some key markets. And Three now actually seems to be giving robust marketing support for HTC’s Windows Phone devices. They are featured prominently on the website and 8X buyers get a free Windows Pro upgrade for their PCs.






It is worth noting that the Windows Phone 8S looks very competitive in the UK prepaid market with a £180 price tag at Three. The Samsung Galaxy S Advance  is £270 and Nokia’s (NOK) Lumia 710 is £200.


HTC recently started looking like Jessica Biel — too bland and too expensive — but with the 8S, it might be getting some of its European budget groove back. It is now starting to look like the November sales momentum HTC just showed will extend to December.


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North Korea considers delaying controversial rocket launch


SEOUL, South Korea (AP) — North Korea may postpone the controversial launch of a long-range rocket that had been slated for liftoff as early as this week, state media said Sunday, as international pressure on Pyongyang to cancel the provocative move intensified.


Scientists have been pushing forward with final preparations for the launch from a west coast site, slated to take place as early as Monday, but are considering "readjusting" the timing, an unidentified spokesman for the Korean Committee for Space Technology told North Korea's state-run Korean Central News Agency.


It was unclear whether diplomatic intervention or technical glitches were behind the delay. A brief KCNA dispatch said scientists and technicians were discussing whether to set new launch dates but did not elaborate.


Word of a possible delay comes just days after satellite photos indicated that snow may have slowed launch preparations, and as officials in Washington, Seoul, Tokyo, Moscow and elsewhere urged North Korea to cancel a liftoff widely seen as a violation of bans against missile activity.


Commercial satellite imagery taken by GeoEye on Dec. 4 and shared Friday with The Associated Press by the 38 North and North Korea Tech websites showed the Sohae site northwest of Pyongyang covered with snow. The road from the main assembly building to the launch pad showed no fresh tracks, indicating that the snowfall may have stalled the preparations.


However, analysts believed rocket preparations would have been completed on time for liftoff as early as Monday.


North Korea announced earlier this month that it would launch a three-stage rocket mounted with a satellite from its Sohae station southeast of Sinuiju sometime between Dec. 10 and Dec. 22. Pyongyang calls it a peaceful bid to send an observational satellite into space, its second attempt this year.


The launch announcement captured global headlines because of its timing: South Korea and Japan hold key elections this month, President Barack Obama begins his second term next month and China has just formed a new leadership. North Koreans also have begun a mourning period for late leader Kim Jong Il, who died on Dec. 17, 2011.


Last week, U.S. Secretary of State Hillary Rodham Clinton said Washington was "deeply concerned" about the launch, and urged foreign ministers from NATO and Russia to demand that Pyongyang cancel its plans.


U.S. and others said the launch would violate U.N. Security Council resolutions banning North Korea from nuclear and missile activity because the rocket shares the same technology used for firing a long-range missile.


North Korea has unveiled missiles designed to target U.S. soil and has tested two atomic bombs in recent years, but has not shown yet that it has mastered the technology for mounting a nuclear warhead to a long-range missile. Six-nation negotiations to offer North Korea much-needed aid in exchange for nuclear disarmament have been stalled since 2009.


China, the North's main ally and aid provider, noted its "concern" after North Korea declared its plans. It acknowledged North Korea's right to develop its space program but said that had to be harmonized with restrictions including those set by the U.N. Security Council.


In Seoul, officials at the Defense Ministry, Joint Chiefs of Staff and the Foreign Ministry said Sunday they couldn't immediately find what might be behind the possible delay.


North Korea may hold off if Washington actively engages Pyongyang in dialogue and promises to ship stalled food assistance to the country, said Koh Yu-hwan, a professor of North Korean studies at Seoul's Dongguk University.


In February, the U.S. agreed to provide 240,000 metric tons of food aid to North Korea in exchange for a freeze in nuclear and missile activities. The deal collapsed after North Korea attempted to launch a long-range rocket in April. That rocket broke up seconds after liftoff.


Analyst Baek Seung-joo of the South Korean state-run Korea Institute for Defense Analyses in Seoul said China must have sent a "very strong" message calling for the North to cancel the launch plans.


"North Korea won't say it would delay the launch due to foreign pressure so that's why they say scientists and technicians are considering delaying it," he said.


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On the edge of the “cliff,” U.S. cities like Charleston












CHARLESTON, South Carolina (Reuters) – For 37 years straight, Joseph P. Riley Jr. has sat behind the mayor’s desk here, shaping this city and its budget.


On a recent afternoon, Riley, 69, reached for a draft copy of next year’s spending plan and wondered aloud about what might get cut should politicians in Washington fail to find an agreement this month, unleashing $ 600 billion worth of spending reductions and tax hikes next year.












Hiring new police officers for the city of 123,000 could be put on hold, Riley said. A new piece of equipment for the fire department would have to wait. Sanitation workers might be in trouble, too.


“The thought that they would allow the economic harm that would ensue if we went over the fiscal cliff is mind-boggling,” said Riley, a Democrat who was elected to his 10th term last year.


Charleston, a beautiful city steeped in history and awash in tourist dollars, would seem at first glance a world apart from the harm that could be caused by the combination of spending cuts and higher taxes. Economists predict its arrival could send the United States hurtling back into a recession.


At its edges, however, Charleston harbors the people who are most vulnerable to Washington’s intransigence, making the city an emblem of a country’s worry and of the powerlessness people feel in the face of Washington’s indecision.


The sting of automatic cuts would be felt acutely by those who work in the defense sector and the poor. They form two prominent groups in Charleston County who may share little but the knowledge that federal belt-tightening is less a nuisance than an existential threat.


In South Carolina, defense spending accounts for $ 15.7 billion in annual economic activity – more than one in 10 dollars spent in the state – and nearly 140,000 jobs.


The Charleston area alone, which includes a large Air Force base and a Navy facility, holds more than 66,000 defense jobs and nearly half of the state’s military economic activity, according to a report released last month by the South Carolina Department of Commerce.


While Charleston, like the rest of the state, has seen a boom in military spending over the last decade, the area has the state’s second-highest concentration of people living in poverty, according to 2010 U.S. census data. More than one in four children live in poverty in the surrounding county.


From the anticipated cuts to the military to the shrinking of the safety net, Charleston shows what’s at stake should the United States fall off the fiscal cliff.


‘DEVASTATION’


A fast-talking engineer originally from Detroit, Michigan, Rebecca Ufkes founded UEC Electronics with her husband in neighboring Hanahan 17 years ago. Walking past employees in blue lab coats assembling components for military vehicles and commercial products last week, Ufkes described the chilling effect the possibility of cuts have had on Charleston’s defense industry.


In September, Ufkes traveled to Washington as a part of a lobbying effort organized by the Aerospace Industry Association, hoping to impress politicians with the dangers facing her 200-person company and its competitors should the anticipated $ 500 billion in defense cuts, over 10 years, come to pass.


She came away encouraged by her state’s largely Republican representation in Washington but frustrated by other lawmakers.


“South Carolina is a very pro-business state,” she said. “They are very keen on economics. It’s just that we are only one of 50 states.”


Ufkes, 48, said she worries not only about the uncertainty that has left defense contractors unsure where to invest but the impending tax increases, which she said will put her company, active in the commercial marketplace as well, at a disadvantage against foreign rivals.


“Probably the solution is not going to be perfect for UEC,” she said, “but I don’t want it to be devastating. Compromise and devastation are not the same thing.”


With a mug declaring, “Failure is not an option,” sitting on her desk, Ufkes predicted that her company would make it, no matter how devastating the cuts are.


“If we don’t survive,” she said. “I don’t know who will.”


NO ‘GIFTS’


Five miles (eight km) from Ufkes’ cutting-edge electronics manufacturer is the struggling North Charleston neighborhood of Chicora-Cherokee, where Bill Stanfield and his wife, Evelyn Oliveira, arrived fresh out of Princeton Theological Seminary 10 years ago.


They founded Metanoia, a development organization focusing on bettering the community by securing housing loans, planting a garden, and running after-school and summer programs.


Through government services like AmeriCorps, the national volunteer group, and funds from sources like the U.S. Department of Housing and Urban Development, Stanfield said his group received nearly a fifth of its funding from the federal government last year.


With politicians facing immense pressure over limiting cuts to entitlements like the Medicare health insurance program for seniors and the Social Security retirement program, advocates for the poor say they expect painful reductions in spending on education and housing.


“I don’t know if our housing program would survive,” Stanfield, 39, said.


Cuts to education will hit South Carolina hard, where the schools have bled money over the last five years.


According to the left-leaning Center on Budget and Policy Priorities, South Carolina’s cuts to education have been the fifth largest in the country, slicing 18 percent off of per-student spending during that period.


The Obama administration, which Republicans consider a profligate spender, has felt like lean times in neighborhoods like Chicora-Cherokee, Stanfield said.


“You know Mitt Romney said that people voted for Obama because of gifts?” Stanfield said. “There’s this misconception that President Obama has been a gravy train of funding. There was more funding under President Bush of these organizations than under Obama.”


‘GAME OF CHICKEN’


Last month, Riley, the Charleston mayor, went to Washington with a group of fellow city leaders, Democrats and Republicans, to lobby the White House and Congress to save cities from drastic cuts.


Vice President Joseph Biden and Democratic leaders from the House of Representatives and Senate met with the mayors. House Speaker John Boehner and other Republican leaders in Congress declined their invitation, Riley said.


While Riley supports Obama’s proposal to increase taxes on income earned over $ 250,000, a sticking point in the negotiations, he and other mayors cautioned that ending the tax-free status of municipal bonds would strangle cities’ access to needed capital.


Riley returned to Charleston feeling like a deal, which could prevent the harshest blows from hitting his city, its residents and jobs, was in the offing. Now, he said, he is not so sure.


“It looks like it’s a game of chicken,” he said, “and there are signals that they are going to go through with it.”


(Reporting By Samuel P. Jacobs Editing by Fred Barbash and Eric Beech)


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Peru’s capital highly vulnerable to major quake












LIMA, Peru (AP) — The earthquake all but flattened colonial Lima, the shaking so violent that people tossed to the ground couldn’t get back up. Minutes later, a 50-foot (15-meter) wall of Pacific Ocean crashed into the adjacent port of Callao, killing all but 200 of its 5,000 inhabitants. Bodies washed ashore for weeks.


Plenty of earthquakes have shaken Peru‘s capital in the 266 years since that fateful night of Oct. 28, 1746, though none with anything near the violence.












The relatively long “seismic silence” means that Lima, set astride one of the most volatile ruptures in the Earth’s crust, is increasingly at risk of being hammered by a one-two, quake-tsunami punch as calamitous as what devastated Japan last year and traumatized Santiago, Chile, and its nearby coast a year earlier, seismologists say.


Yet this city of 9 million people is sorely unprepared. Its acute vulnerability, from densely clustered, unstable housing to a dearth of first-responders, is unmatched regionally. Peru’s National Civil Defense Institute forecasts up to 50,000 dead, 686,000 injured and 200,000 homes destroyed if Lima is hit by a magnitude-8.0 quake.


“In South America, it is the most at risk,” said architect Jose Sato, director of the Center for Disaster Study and Prevention, or PREDES, a non-governmental group financed by the charity Oxfam that is working on reducing Lima’s quake vulnerability.


Lima is home to a third of Peru’s population, 70 percent of its industry, 85 percent of its financial sector, its entire central government and the bulk of international commerce.


“A quake similar to what happened in Santiago would break the country economically,” said Gabriel Prado, Lima’s top official for quake preparedness. That quake had a magnitude of 8.8.


Quakes are frequent in Peru, with about 170 felt by people annually, said Hernando Tavera, director of seismology at the country’s Geophysical Institute. A big one is due, and the chances of it striking increase daily, he said. The same collision of tectonic plates responsible for the most powerful quake ever recorded, a magnitude-9.5 quake that hit Chile in 1960, occurs just off Lima’s coast, where about 3 inches of oceanic crust slides annually beneath the continent.


A 7.5-magnitude quake in 1974 a day’s drive from Lima in the Cordillera Blanca range killed about 70,000 people as landslides buried villages. Seventy-eight people died in the capital. In 2007, a 7.9-magnitude quake struck even closer, killing 596 people in the south-central coastal city of Pisco.


A shallow, direct hit is the big danger.


More than two in five Lima residents live either in rickety structures on unstable, sandy soil and wetlands that amplify a quake’s destructive power or in hillside settlements that sprang up over a generation as people fled conflict and poverty in Peru’s interior. Thousands are built of colonial-era adobe.


Most quake-prone countries have rigorous building codes to resist seismic events. In Chile, if engineers and builders don’t adhere to them they can face prison. Not so in Peru.


“People are building with adobe just as they did in the 17th century,” said Carlos Zavala, director of Lima’s Japanese-Peruvian Center for Seismic Investigation and Disaster Mitigation.


Environmental and human-made perils compound the danger.


Situated in a coastal desert, Lima gets its water from a single river, the Rimac, which a landslide could easily block. That risk is compounded by a containment pond full of toxic heavy metals from an old mine that could rupture and contaminate the Rimac, said Agustin Gonzalez, a PREDES official advising Lima’s government.


Most of Lima’s food supply arrives via a two-lane highway that parallels the river, another potential chokepoint.


Lima’s airport and seaport, the key entry points for international aid, are also vulnerable. Both are in Callao, which seismologists expect to be scoured by a 20-foot (6-meter) tsunami if a big quake is centered offshore, the most likely scenario.


Mayor Susana Villaran’s administration is Lima’s first to organize a quake-response and disaster mitigation plan. A February 2011 law obliged Peru’s municipalities to do so. Yet Lima’s remains incipient.


“How are the injured going to be attended to? What is the ability of hospitals to respond? Of basic services? Water, energy, food reserves? I don’t think this is being addressed with enough responsibility,” said Tavera of the Geophysical Institute.


By necessity, most injured will be treated where they fall, but Peru’s police have no comprehensive first-aid training. Only Lima’s 4,000 firefighters, all volunteers, have such training, as does a 1,000-officer police emergency squadron.


But because the firefighters are volunteers, a quake’s timing could influence rescue efforts.


“If you go to a fire station at 10 in the morning there’s hardly anyone there,” said Gonzalez, who advocates a full-time professional force.


In the next two months, Lima will spend nearly $ 2 million on the three fire companies that cover downtown Lima, its first direct investment in firefighters in 25 years, Prado said. The national government is spending $ 18 million citywide for 50 new fire trucks and ambulances.


But where would the ambulances go?


A 1997 study by the Pan American Health Organization found that three of Lima’s principal public hospitals would likely collapse in a major quake, but nothing has been done to reinforce them.


And there are no free beds. One public hospital, Maria Auxiliadora, serves more than 1.2 million people in Lima’s south but has just 400 beds, and they are always full.


Contingency plans call for setting up mobile hospitals in tents in city parks. But Gonzalez said only about 10,000 injured could be treated.


Water is also a worry. The fire threat to Lima is severe — from refineries to densely-backed neighborhoods honeycombed with colonial-era wood and adobe. Lima’s firefighters often can’t get enough water pressure to douse a blaze.


“We should have places where we can store water not just to put out fires but also to distribute water to the population,” said Sato, former head of the disaster mitigation department at Peru’s National Engineering University.


The city’s lone water-and-sewer utility can barely provide water to one-tenth of Lima in the best of times.


Another big concern: Lima has no emergency operations center and the radio networks of the police, firefighters and the Health Ministry, which runs city hospitals, use different frequencies, hindering effective communication.


Nearly half of the city’s schools require a detailed evaluation to determine how to reinforce them against collapse, Sato said.


A recent media blitz, along with three nationwide quake-tsunami drills this year, helped raise consciousness. The city has spent more than $ 77 million for retention walls and concrete stairs to aid evacuation in hillside neighborhoods, Prado said, but much more is needed.


At the biggest risk, apart from tsunami-vulnerable Callao, are places like Nueva Rinconada.


A treeless moonscape in the southern hills, it is a haven for economic refugees who arrive daily from Peru’s countryside and cobble together precarious homes on lots they scored into steep hillsides with pickaxes.


Engineers who have surveyed Nueva Rinconada call its upper reaches a death trap. Most residents understand this but say they have nowhere else to go.


Water arrives in tanker trucks at $ 1 per 200 liters (52 gallons) but is unsafe to drink unless boiled. There is no sanitation; people dig their own latrines. There are no streetlamps, and visibility is erased at night as Lima’s bone-chilling fog settles into the hills.


Homes of wood, adobe and straw matting rest on piled-rock foundations that engineers say will crumble and rain down on people below in a major quake.


A recently built concrete retaining wall at the valley’s head lies a block beneath the thin-walled wood home of Hilarion Lopez, a 55-year-old janitor and community leader. It might keep his house from sliding downhill, but boulders resting on uphill slopes could shake loose and crush him and his neighbors.


“We’ve made holes and poured concrete around some of the more unstable boulders,” he says, squinting uphill in a strong late morning sun.


He’s not so worried if a quake strikes during daylight.


“But if I get caught at night? How do I see a rock?”


___


Associated Press writer Franklin Briceno contributed to this report.


___


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Orlando Bloom’s Legolas returns to Middle Earth in 2014′s “There and Back Again”












LOS ANGELES (TheWrap.com) – Legolas was a fan favorite in Peter Jackson‘s “Lord of the Rings” trilogy, but J.R.R. Tolkien enthusiasts won’t see the warrior Elf return to Middle Earth until 2014 when “The Hobbit: There and Back Again” hits theaters.


Entertainment Weekly published the first image of Orlando Bloom reprising his role and he looks pretty much the same, with the exception of his very blue eyes (weren’t they brown before?).












It’s true that the character is not featured in the book this trilogy is being adapted from, but luckily for Bloom’s bank account, his father is.


“He’s Thranduil’s son, and Thranduil is one of the characters in ‘The Hobbit,’” Jackson explained. “And because elves are immortal it makes sense Legolas would be part of the sequence in the Woodland Realm.”


If you don’t recognize the man standing next to Legolas, it’s because he’s a new face in the franchise. Bard the Bowman – played by Luke Evans – is a heroic human Laketown warrior who (if you couldn’t tell by his name) is also quite the marksman. He’ll come into the picture when “The Hobbit: The Desolation of Smaug” lands in theaters on December 13, 2013.


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How one startup is overhauling Android to make it enterprise-ready












The common misconception that Android isn’t secure enough for the business world or government employees is about to change. A Boston-based startup called Optio Labs has created a custom version of Google’s (GOOG) mobile operating system that can control what can and cannot be accessed depending on location, network or running apps. The technology can even allow a phone to display sensitive company data or block things like texting and camera usage based on room-specific security and access settings, Technology Review reported. This unique feature can utilize a Bluetooth beacon that, when in range, would send a cryptographic tether to a device. It would also be possible to use near field communications to view sensitive information, theoretically forcing workers to “bump” their bosses phone to get initial access.


“You can dream up just about any rule, it can be your GPS location, or an indoor location detection: when you are in this specific room you can use these apps and connect to this data, but the moment you walk out we will delete the data, shut down the apps, prevent you from getting access to them,” said Jules White, co-founder of the company.












The technology could prevent information from being lost or stolen and can increase productivity by stopping workers from texting and spending time on social networking sites while in the office. Optio Labs is said to have sold its custom Android software and accompanying policy-management system to undisclosed systems integrators and smartphone manufacturers. Android devices containing the software are expected to arrive on the market in late 2013.


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Supreme Court: Both sides in gay marriage debate voice optimism


Both sides of the contentious debate over same-sex marriage in America are expressing optimism over the news Friday that the US Supreme Court has agreed to take up two potential landmark gay rights cases.


The high court announced it would hear arguments in a case testing the constitutionality of California’s Prop. 8 ban on same-sex marriage.


It also said it would hear the case of an elderly New York City woman who claims the federal Defense of Marriage Act (DOMA) violates her right to have her same-sex marriage recognized and respected by the federal government on the same terms as marriages of opposite-sex couples.


Gay marriage laws around the globe


DOMA restricts receipt of federal spousal benefits to marriages comprised of one man and one woman. Same-sex spouses who are legally married in their home states are nonetheless barred from receiving federal benefits under the 1996 law.


The high court action comes a month after voters in three states – Maryland, Washington, and Maine – agreed to join six other states and the District of Columbia in embracing same-sex marriages.


“With our wins at the ballot box last month and the fight for marriage equality reaching our nation’s highest court, we have reached a turning point in this noble struggle,” said Chad Griffin, president of the gay rights group, Human Rights Campaign.


“Today’s announcement gives hope that we will see a landmark Supreme Court ruling for marriage this term,” he said in a statement.


Kate Kendell, of the National Center for Lesbian Rights, sounded similarly optimistic.


“We are confident the Supreme Court will strike down DOMA once and for all next year, and, after four long years, will finally erase the stain of Proposition 8 and restore marriage equality to California couples,” she said.


“The day is now clearly in sight when the federal government, the state of California, and every state will recognize that same-sex couples and their children are entitled to the same respect and recognition as every other family,” Ms. Kendell said.


At the same time, those defending the traditional definition of marriage – as the union of one man and one woman – also viewed the court’s action as a step forward toward legal vindication of their position.


John Eastman, chairman of the National Organization for Marriage, said the court’s decision to take up the Prop. 8 case suggests an intent by the justices to reinstate California’s ban on same-sex marriage.


“We believe it is a strong signal that the court will reverse the lower courts and uphold Proposition 8,” Mr. Eastman said.


“Had the Supreme Court agreed with the lower courts’ decisions invalidating Proposition 8, it could simply have declined to grant … the case,” Eastman said. “It’s a strong signal that the justices are concerned with the rogue rulings that have come out of San Francisco.”


Eastman added that the Prop. 8 appeals court decision was written by Judge Stephen Reinhart. “It’s worth noting that Judge Reinhart is the most overruled judge in America. I think this case will add to his record.”


Others disagreed.


Evan Wolfson, founder and president of Freedom to Marry, said the high court action opens the way for a civil rights breakthrough for same-sex spouses.


“Gay and lesbian couples in California – and indeed all over this country – now look to the Supreme Court to affirm that the Constitution does not permit states to strip something as important as the freedom to marry away from one group of Americans,” he said.


Mr. Wolfson urged the justices to move quickly to affirm the 10 federal court judges who have ruled in recent years that DOMA is unconstitutional.


“When it comes to the whole federal safety net that accompanies marriage – access to Social Security survivorship, health coverage, family leave, fair tax treatment, family immigration, and over 1,000 other protections and responsibilities – couples who are legally married in the states should be treated by the federal government as what they are: married,” Wolfson said.


Others viewed the high court’s task in broader terms.


“Today, the Supreme Court has put itself on the path of deciding the most contentious civil rights issue of our day,” said David Cohen, a law professor at Drexel University in Philadelphia.


“By taking both cases, the court is boldly asserting its role in same-sex marriage,” he said.


Professor Cohen said the justices have a choice to either follow the example of prior courts that have ruled to expand civil rights or those that ruled in ways that contracted civil rights. Given shifting public opinion in support of gay rights and same-sex marriage, the professor says it is unlikely that the court will rule against a broader conception of marriage.


Jim Campbell, a lawyer with the conservative group, Alliance Defending Freedom, stressed that Americans have a right to preserve the traditional definition of marriage. He said the institution forms a “fundamental building block of civilization.”


“Marriage between a man and a woman is a universal good that diverse cultures and faiths have honored throughout the history of Western civilization,” he said. “Marriage expresses the truth that men and women bring distinct, irreplaceable gifts to family life.”


Gay marriage laws around the globe



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Roche breast cancer drug extends overall survival












ZURICH (Reuters) – Swiss pharma group Roche‘s drug Perjeta significantly extended the lives of women with an aggressive and incurable form of breast cancer compared to a placebo, according to new data from a late-stage study presented on Saturday.


The detailed data presented at the San Antonio Breast Cancer Symposium found that the risk of death was reduced by 34 percent in women treated with a combination treatment of the drugs Perjeta and Herceptin plus chemotherapy compared to women treated with Herceptin, chemotherapy and a placebo, Roche said.












Roche is hoping that the Perjeta combination will become the standard treatment for women with a form of cancer known as HER2-positive, which makes up about a quarter of all breast cancers and has no cure.


At the time of the analysis, median overall survival had not yet been reached in people receiving the Perjeta combination, as more than half of these people continued to survive, Roche said.


Median overall survival was more than three years for people who received Herceptin and chemotherapy, Roche said, adding no new safety signals had been observed in the phase III study.


“This treatment combination with Perjeta is the first to have significantly extended survival compared to Herceptin and chemotherapy in people with previously untreated HER2-positive metastatic breast cancer,” Roche’s Chief Medical Officer Hal Barron said in the statement.


Breast cancer is the most common cancer among women worldwide, with about 1.4 million new cases diagnosed each year and more than 450,000 women dying of the disease annually, according to the World Health Organisation.


Perjeta, also known as pertuzumab, is a personalized medicine that targets a protein found in high quantities on the outside of cancer cells in HER2-positive cancers.


It was granted approval by U.S. health regulators in June. Roche is awaiting a decision from European regulators.


Vontobel analyst Andrew Weiss forecasts peak sales of 2 billion Swiss francs ($ 2.15 billion) for the drug.


Roche is also developing an “armed antibody” known as TDM-1 as a treatment for HER2-positive breast cancer. TDM-1 combines Herceptin with a derivative of a powerful type of chemotherapy and is designed to reduce unpleasant side effects. ($ 1 = 0.9313 Swiss francs)


(Reporting by Silke Koltrowitz and Caroline Copley; Editing by Paul Tait)


Medications/Drugs News Headlines – Yahoo! News


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Egyptian opposition to shun Mursi’s national dialogue












CAIRO (Reuters) – President Mohamed Mursi was expected to press ahead on Saturday with talks on ways to end Egypt‘s worst crisis since he took office even though the country’s main opposition leaders have vowed to stay away.


Cairo and other cities have been rocked by violent protests since November 22, when Mursi promulgated a decree awarding himself sweeping powers that put him above the law.












The upheaval in the most populous Arab nation, following the fall of Hosni Mubarak last year, worries the West, in particular the United States, which has given it billions of dollars in military and other aid since Egypt made peace with Israel in 1979.


Mursi’s deputy raised the possibility that a referendum set for December 15 on a new constitution opposed by liberals might be delayed. But the concession only goes part-way towards meeting the demands of the opposition, who also want Mursi to scrap the decree awarding himself wide powers.


On Friday, large crowds of protesters surged around the presidential palace, breaking through barbed wire barricades and climbing on tanks guarding the seat of Egypt’s first freely elected president, who took office in June.


As the night wore on, tens of thousands of opposition supporters were still at the palace, waving flags and urging Mursi to “Leave, leave”.


“AS LONG AS IT TAKES”


“We will stay here for as long as it takes and will continue to organize protests elsewhere until President Mursi cancels his constitutional decree and postpones the referendum,” said Ahmed Essam, 28, a computer engineer and a member of the liberal Dostour party.


Vice President Mahmoud Mekky issued a statement saying the president was prepared to postpone the referendum if that could be done without legal challenge.


Mursi’s planned dialogue meeting was expected to go ahead on Saturday in the absence of most opposition factions. “Everything will be on the table,” a presidential source said.


Mursi could be joined by some senior judiciary figures and politicians such as Ayman Nour, one of the candidates in Mubarak’s only multi-candidate presidential race, in 2005, in which he was unsurprisingly trounced.


The opposition has demanded that Mursi rescind the decree giving himself wide powers and delay the vote set for December 15 on a constitution drafted by an Islamist-led assembly which they say fails to meet the aspirations of all Egyptians.


EXPAT VOTE DELAYED


The state news agency reported that the election committee had postponed the start of voting for Egyptians abroad until Wednesday, instead of Saturday as planned. It did not say whether this would affect the timing of voting within Egypt.


Ahmed Said, leader of the liberal Free Egyptians Party, told Reuters that delaying expatriate voting was intended to seem like a concession but would not change the opposition’s stance.


The opposition organized marches converging on the palace which Republican Guard units had ringed with tanks and barbed wire on Thursday after violence between supporters and opponents of Mursi killed seven people and wounded 350.


Islamists, who had obeyed a military order for demonstrators to leave the palace environs, held funerals on Friday at Cairo’s al-Azhar mosque for six Mursi partisans who were among the dead.


“With our blood and souls, we sacrifice to Islam,” they chanted.


A group led by leftist opposition leader Hamdeen Sabahy has called for an open-ended protest at the palace.


Some pro-Mursi demonstrators gathered in a mosque not far from the palace, but said they would not march towards the palace to avoid a repeat of the violence that took place on Wednesday night.


In a speech late on Thursday, Mursi had refused to retract his decree or cancel the referendum on the constitution, but offered talks on the way forward after the referendum.


The National Salvation Front, the main opposition coalition, said it would not join the dialogue. The Front’s coordinator, Mohamed ElBaradei, a Nobel peace laureate, dismissed the offer as “arm-twisting and imposition of a fait accompli”.


ElBaradei said that if Mursi were to scrap the decree with which he awarded himself extra powers and postpone the referendum “he will unite the national forces”.


Murad Ali, spokesman for the Muslim Brotherhood’s Freedom and Justice Party, said opposition reactions were sad: “What exit to this crisis do they have other than dialogue?” he asked.


(This story corrects Mursi’s title to president in paragraph 1)


(Additional reporting by Omar Fahmy; Writing by Giles Elgood; Editing by Michael Roddy and Paul Tait)


World News Headlines – Yahoo! News


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“Gangnam Style” singer Psy apologizes for past anti-U.S. songs












LOS ANGELES (Reuters) – The South Korean pop singer behind the viral smash hit “Gangnam Style” apologized on Friday for past concerts featuring anti-American lyrics, ahead of a holiday performance to be attended by U.S. President Barack Obama and his family.


Psy issued the apology after reports surfaced in the United States on Friday about his participation in two performances critical of the U.S. military in 2004.












Psy’s “Gangnam Style” Korean pop and dance video is now the most-watched video ever on YouTube, with more than 900 million views since it was first uploaded in July.


“While I’m grateful for the freedom to express one’s self, I’ve learned there are limits to what language is appropriate and I’m deeply sorry for how these lyrics could be interpreted,” the rapper said in a statement.


“I will forever be sorry for any pain I have caused by those words,” he added.


In one performance, which Psy said was from eight years ago, the rapper protested the deaths of two teenage South Korean girls who were run over by a U.S. tank stationed in the country.


In a separate performance, Psy was critical of the U.S.-led invasion of Iraq and its occupation, in which South Korean forces participated.


Psy is scheduled to perform at the annual “Christmas in Washington” television special that will also be attended by Obama and his family, the White House said on Friday. Broadcaster TNT said Psy would still perform as planned.


(Reporting by Eric Kelsey; Additional reporting by Mark Felsenthal in Washington; Editing by Jill Serjeant and Peter Cooney)


Music News Headlines – Yahoo! News


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